Domain Interaction Graph Guided ExploreR (DIGGER) integrates protein-protein interactions and domain-domain interactions into a joint graph and maps interacting residues to exons. DIGGER allows the users to query exons or isoforms individually or as a set to visually explore their interactions. The following modes of DIGGER can be used interchangeably:

Isoform-Level analysis

Visualize the interacting domains of proteins and compare the interactions of different isoforms.

Exon-Level analysis

Input an exonic region to analyze the effect of alternative splicing events on protein interactions.

Network-Level analysis

Explore interactions between multiple isoforms and generate a specific subnetwork from a list of protein variants or transcripts.

If you use DIGGER, please cite:

Zakaria Louadi, Kevin Yuan, Alexander Gress, Olga Tsoy, Olga V Kalinina, Jan Baumbach, Tim Kacprowski*, Markus List*. DIGGER: exploring the functional role of alternative splicing in protein interactions, Nucleic Acids Research.
* Joint last authors.

Reminder: DIGGER works better on Chromium-based browsers and Firefox. If you need help, have a look at our documentation or contact Zakaria Louadi.